Tissue dynamics: from in vivo experiments to in silico modelling

21-26 August 2022
Manchester Central Convention Complex, 
Manchester UK 
This meeting is a mini colloquium as part of the larger CMD29. 
Organising committee: 
Lea-Laetitia Pontani (IBPS)
Thibault Bertrand (Imperial College London)
​Joseph d’Alessandro (Institut Jacques Monod)

Workshop overview

One of the most striking features of animal cells is their ability to change shape and migrate in response to environmental cues. At the tissue scale, cells behave and respond collectively to chemical and mechanical signals, giving rise to complex orchestrated processes such as morphogenesis or tumor growth. Developing a quantitative description of tissue dynamics is crucial not only for our fundamental understanding of key developmental and physiological processes but also for our very practical strategies in dealing with a variety of pathologies. 
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In the past decade, progress in this field was made on many fronts and many levels of complexity including: (1) in vivo and in vitro experiments by cell biologists and biophysicists which retain the complexity of tissues [1-3], (2) the development of biomimetic experiments retaining only key aspects of the underlying system, offering a well-controlled experimental platform for soft matter physicists [4,5] and (3) an explosion of theoretical and in silico models which are minimal physical models and often retain only universal features (including continuum models, vertex models, deformable particles models, phase field models) [6-8]. 
While very active internationally, this field is nonetheless scattered across diverse specialist communities and lacks unifying principles. This mini-colloquium aims at bringing together both advanced and early career scientists from these diverse communities to foster discussions at the interface of (1) theory and experiments and (2) soft condensed matter physics and cell biology. By highlighting the complementarity of these different approaches, our goal is to find universal features in tissue dynamics (e.g. including pattern formation, collective migration, …). In doing so, we will also raise emerging questions in the field. For instance, a large body of literature is still devoted to two dimensional tissues both experimentally and in terms of models while recent progress in microscopy has brought 3D in vivo experiments into reach with applications including the folding process of drosophila wing during morphogenesis or the dynamics of the bone marrow during leukaemia. Proper 3D in silico models are on the other hand still rare and we hope to trigger conversations and potential collaborations in these emerging areas.

To find out more about this event, please follow this link: 
​iop.eventsair.com/cmd29/tissue-dynamics-from-in-vivo-experiments-to-in-silico-modelling